Looking for real results on your weight loss journey in Durham? GLP-1 medications like Ozempic and Semaglutide are changing the game by helping people control cravings, manage blood sugar, and lose weight more effectively. But the secret isn’t just the medication—it’s combining it with expert medical guidance.

That’s why we’ve put together this list of 10 trusted weight loss clinics in Durham that offer medically supervised programs, including support with GLP-1 treatments like Semaglutide. These providers take a personalized approach to help you lose weight safely—and keep it off.

1. Duke Lifestyle and Weight Management Center

Website: dukehealth.org

Address: 3475 Erwin Rd, Durham, NC 27705

Phone: (919) 660-6660

With over 50 years of experience, Duke’s center offers a comprehensive approach to weight loss, combining medical treatments like GLP-1 medications with lifestyle changes. Their multidisciplinary team ensures each patient receives personalized care tailored to their unique needs.

2. Metabolic Research Center – Durham

Website: emetabolic.com

Address: 6011 Fayetteville Rd, Ste 105, Durham, NC 27713

Phone: (919) 887-2815

This clinic offers customized weight loss programs, including compounded GLP-1 medications like Semaglutide. Their holistic approach includes personalized meal plans, one-on-one coaching, and hormone balancing to support sustainable results.

3. Durham Women’s Clinic

Website: durhamwomensclinic.com

Address: 209 E Carver St, Durham, NC 27704

Phone: (919) 471-2273

Specializing in women’s health, this clinic offers medically supervised weight loss programs that may include Semaglutide. They cater to patients in various life stages—from postpartum to menopause—helping them reach their goals with safe, targeted strategies.

4. Physicians WEIGHT LOSS Centers – Durham

Website: pwlcdurhamnc.com

Address: 3823 Guess Rd, Durham, NC 27705

Phone: (919) 479-1234

This clinic offers personalized weight loss programs incorporating GLP-1 medications, B12 shots, and tailored diet plans. Their supportive staff works with each patient to help them reach—and maintain—their healthiest weight.

5. Simonds Metabolic and Weight Loss Center

Website: simondsmetabolics.com

Address: 6905 Fayetteville Rd, Ste 201, Durham, NC 27713

Phone: (919) 490-8899

Founded by Dr. Simonds, this clinic provides a wide range of prescription weight loss treatments, including Phentermine and GLP-1s like Semaglutide. Their in-house pharmacy makes getting started simple and convenient.

6. Blissful Wellness – Telehealth

Website: getskinnyjax.com

Address: Telehealth services in Durham, NC

Phone: (888) 978-1828

Blissful Wellness offers virtual Semaglutide prescriptions with expert medical oversight. Led by Dr. Elyssa Blissenbach, their team helps patients nationwide through personalized, at-home treatment plans that are easy to follow and effective.

7. Concierge MD – Durham

Website: conciergemdla.com

Address: Telehealth services in Durham, NC

Phone: (877) 847-5533

This concierge service offers Semaglutide injections delivered to your door. With lab testing, virtual consults, and weekly medication shipments, they make it easy for Durham residents to access safe, medically guided weight loss treatment at home.

8. Tannan Plastic Surgery

Website: tannanplasticsurgery.com

Address: 2304 Wesvill Ct, Ste 360, Raleigh, NC 27607

Phone: (919) 797-0996

Dr. Shruti Tannan brings her surgical precision and aesthetic eye to weight loss, offering Semaglutide injections to patients seeking lasting, transformative results. Their boutique practice focuses on thoughtful, individualized care.

9. Medical Day Spa of Chapel Hill

Website: chapelhilldayspa.com

Address: 109 Conner Dr, Ste 220, Chapel Hill, NC 27514

Phone: (919) 904-7111

This physician-led day spa offers a holistic Semaglutide weight loss program that includes nutrition planning, lifestyle support, and weekly follow-ups. It’s a relaxing yet professional setting designed to help you feel your best inside and out.

10. Central Compounding Center

Website: centralcompounding.com

Address: 2601 Blue Ridge Rd, Ste 100, Raleigh, NC 27607

Phone: (919) 781-1050

As a specialty pharmacy, Central Compounding Center plays a key role in helping patients access customized weight loss medications, including GLP-1s like Semaglutide. They partner with local clinics and directly support patients with affordable, personalized treatment options.

Take the First Step Toward Better Health

Whether you’re looking for in-person support or the convenience of telehealth, Durham has a wealth of options for medically supervised weight loss. These clinics combine advanced medications like Ozempic and Semaglutide with personalized care to help you reach your goals safely. Don’t wait—book a consultation today and start building a healthier future.